Eight-year-old Jack, his sister, Annie, and Peanut, the mouse ride in a tree house to the Amazon Rain Forest where they encounter giant ants, piranhas, jaguars, and a hungry crocodile.

Her funding rejected by the Royal Society, and pursued by an obsessed member of German nobility, Lily travels from London to the Amazon jungle and enlists Frank's questionable services to guide her downriver in search of an ancient tree with unparalleled healing abilities which would change the future of medicine. Thinking she sees Frank for who he truly is -- a pun-loving con man who embellishes danger on his tours in order to get better tips from...